CCC does reference standards
Tauto Biotech, our Chinese friends and producers of our line of type J instruments, have been using CCC to make quality reference standards for many years. In fact, our entire line of reference standards are produced by Tauto Biotech HSCCC instruments.
I recently asked Jack Jiang, a Tauto employee, about Tauto’s experience using CCC to produce reference standards.
1) How does the production of reference standards using HSCCC benefit
Tauto Biotech and how did it all start?Since the year 1999 when Tauto was founded, the company has been devoting efforts on the development of the chemical database of natural monomers and the separation work of botanical reference materials by HSCCC. The separation with HSCCC technology can prove the efficiency of active components separation with the related HSCCC equipment, while it can also get the wanted active components with high purity and low cost.2) Why use CCC rather than other techniques such as HPLC to produce
reference standards?
Based upon the features of CCC, it has its own advantages in separation of reference materials:large injection volume, high resolution, high yield rate, good reproducibility,easy to scale-up, low cost in production, no consumption of consumables, low maintenance fee.
3) Are there any instances where HSCCC was particularly useful for
producing reference standards? (for example where the purity is
superior or where reference standards can be produce much more
efficiently?
Instance: Separation of Ginkgolide J, Huperzine B, Isomers of Gambogic Acid
4) What are the most important things to know for someone who is
considering adopting the use of HSCCC for the production of reference
standards?a. Check the characteristics of the sample to see whether it is suitable for the separation by CCC.b. The most important technology point is the selection of solvent system for HSCCC separation